Synthesis and Development of Novel Neuroprotective Drugs
Collaborators
- John Marshall, PhD, Brown University
- John C. Williams, PhD, Rhode Island College
- Christopher Seto, PhD, Brown University
Summary
Building infrastructure and providing leading-edge equipment to our scientists is critical to keeping Rhode Island at the forefront of competitive research. This collaboration between Brown University and Rhode Island College seeks to purchase the recently developed 'Milestone MultiSYNTH labstation' which will allow researchers to create commercial amounts of pharmaceuticals, thereby increasing the state's research potential. The Milestone MultiSYNTH is the only microwave synthesizer that can operate in both single-mode and multi-mode formats, a valuable advantage.
Through previous studies, Dr. John Marshall and Dr. John C. Williams have discovered a lead compound that improves the tolerance of treatment for patients suffering from stroke, multiple sclerosis and traumatic brain injuries. With help from the MultiSYNTH labstation, this team will be able to get more research done with less time and expense.
This project will also build upon a previous STAC award to Dr. Wolfgang Peti (Brown University) by employing nuclear magnetic resonance (NMR) and isothermal titration calorimetry (ITC). Dr. Peti received funding from STAC in 2008 to purchase a state-of-the-art Isothermal Titration Calorimeter that supports proteomics research. This team will bring together pharmacology, chemistry, pharmaceutical and clinical establishments to pool expertise and resources within the state.
